Abstract

CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups. When focusing on structural genomics (SG) structures, we observe that the number of new folds for CATH v3.5 is slightly less than for previous releases, and this observation suggests that we may now know the majority of folds that are easily accessible to structure determination. We have improved the accuracy of our functional family (FunFams) sub-classification method and the CATH sequence domain search facility has been extended to provide FunFam annotations for each domain. The CATH website has been redesigned. We have improved the display of functional data and of conserved sequence features associated with FunFams within each CATH superfamily.

Keywords

BiologyHomology (biology)Computational biologySequence alignmentSequence (biology)Functional genomicsStructural genomicsDomain (mathematical analysis)GenomeConserved sequenceFunctional analysisGenomicsSequence homologyGeneticsEvolutionary biologyProtein structureBase sequencePeptide sequenceGeneMathematics

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Publication Info

Year
2012
Type
article
Volume
41
Issue
D1
Pages
D490-D498
Citations
213
Access
Closed

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Ian Sillitoe, Alison Cuff, Benoît H. Dessailly et al. (2012). New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures. Nucleic Acids Research , 41 (D1) , D490-D498. https://doi.org/10.1093/nar/gks1211

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DOI
10.1093/nar/gks1211