Keywords
Related Publications
The noncanonical NF‐κB pathway
Summary: The noncanonical nuclear factor‐κB (NF‐κB) signaling pathway mediates activation of the p52/RelB NF‐κB complex and, thereby, regulates specific immunological processes....
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
In mammals, the canonical nuclear factor κB (NF-κB) signaling pathway activated in response to infections is based on degradation of IκB inhibitors. This pathway depends on the ...
NF-κB: a key role in inflammatory diseases
NF-κB in defense and diseaseActivation of the NF-κB/Rel transcription family, by nuclear translocation of cytoplasmic complexes, plays a central role in inflammation through its...
The NF- B Family of Transcription Factors and Its Regulation
Nuclear factor-kappaB (NF-kappaB) consists of a family of transcription factors that play critical roles in inflammation, immunity, cell proliferation, differentiation, and surv...
The IKK Complex, a Central Regulator of NF- B Activation
The IKK kinase complex is the core element of the NF-kappaB cascade. It is essentially made of two kinases (IKKalpha and IKKbeta) and a regulatory subunit, NEMO/IKKgamma. Additi...
Publication Info
- Year
- 2010
- Type
- review
- Volume
- 21
- Issue
- 1
- Pages
- 71-85
- Citations
- 1135
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1038/cr.2010.177