Abstract
Nuclear factor-kappaB (NF-kappaB) consists of a family of transcription factors that play critical roles in inflammation, immunity, cell proliferation, differentiation, and survival. Inducible NF-kappaB activation depends on phosphorylation-induced proteosomal degradation of the inhibitor of NF-kappaB proteins (IkappaBs), which retain inactive NF-kappaB dimers in the cytosol in unstimulated cells. The majority of the diverse signaling pathways that lead to NF-kappaB activation converge on the IkappaB kinase (IKK) complex, which is responsible for IkappaB phosphorylation and is essential for signal transduction to NF-kappaB. Additional regulation of NF-kappaB activity is achieved through various post-translational modifications of the core components of the NF-kappaB signaling pathways. In addition to cytosolic modifications of IKK and IkappaB proteins, as well as other pathway-specific mediators, the transcription factors are themselves extensively modified. Tremendous progress has been made over the last two decades in unraveling the elaborate regulatory networks that control the NF-kappaB response. This has made the NF-kappaB pathway a paradigm for understanding general principles of signal transduction and gene regulation.
Keywords
Transcription factorBiologySignal transductionIκB kinaseCell biologyNF-κBPhosphorylationNFKB1CytosolKinaseGeneGeneticsBiochemistryEnzyme
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Publication Info
- Year
- 2009
- Type
- review
- Volume
- 1
- Issue
- 4
- Pages
- a000034-a000034
- Citations
- 2706
- Access
- Closed
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Cite This
Andrea Oeckinghaus,
Sankar Ghosh
(2009).
The NF- B Family of Transcription Factors and Its Regulation.
Cold Spring Harbor Perspectives in Biology
, 1
(4)
, a000034-a000034.
https://doi.org/10.1101/cshperspect.a000034
Identifiers
- DOI
- 10.1101/cshperspect.a000034