Abstract
Lipid oxidation has been shown to be a prominent feature of atherosclerosis. The presence of isoprostanes and other lipid oxidation products has been clearly demonstrated in lesions. Furthermore, antibodies to oxidized phospholipids have been identified in animal and human models. Recent evidence suggests that oxidized phospholipids may activate all vascular cell types. The identification and isolation of particular oxidative products has provided some important information about the receptors for these active lipids.
Keywords
IsoprostanesChemistryOxidative stressBiochemistryLipid peroxidation
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Publication Info
- Year
- 1998
- Type
- review
- Volume
- 9
- Issue
- 5
- Pages
- 441-448
- Citations
- 170
- Access
- Closed
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Cite This
Joseph L. Witztum,
Judith A. Berliner
(1998).
Oxidized phospholipids and isoprostanes in atherosclerosis.
Current Opinion in Lipidology
, 9
(5)
, 441-448.
https://doi.org/10.1097/00041433-199810000-00008
Identifiers
- DOI
- 10.1097/00041433-199810000-00008