Keywords
Affiliated Institutions
Related Publications
Chemical and physical carcinogenesis: advances and perspectives for the 1990s.
Carcinogenesis is a multistage process driven by carcinogen-induced genetic and epigenetic damage in susceptible cells that gain a selective growth advantage and undergo clonal ...
p53 Mutations in Human Cancers
Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer. The p53 mutational spectrum differs among cancers ...
Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression
Mutant forms of the gene encoding the tumor suppressor p53 are found in numerous human malignancies, but the physiologic function of p53 and the effects of mutations on this fun...
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus
Upon cellular DNA damage, the p53 tumor suppressor protein transmits a signal to genes that control the cell cycle and apoptosis. One function of p53 that is important for its r...
Identification of p53 as a Sequence-Specific DNA-Binding Protein
The tumor-suppressor gene p53 is altered by missense mutation in numerous human malignancies. However, the biochemical properties of p53 and the effect of mutation on these prop...
Publication Info
- Year
- 1999
- Type
- review
- Volume
- 428
- Issue
- 1-2
- Pages
- 23-32
- Citations
- 163
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1016/s1383-5742(99)00028-9