PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer

Andrea Cercek; Melissa Lumish; Jenna Sinopoli; Jill Weiss; Jinru Shia; Michelle F. Lamendola-Essel; Imane H. El Dika; Neil H. Segal; Marina Shcherba; Ryan Sugarman; Zsofia K. Stadler; Rona Yaeger; J. Joshua Smith; Benoı̂t Rousseau; Guillem Argilés; Mitesh Patel; Avni M. Desai; Leonard B. Saltz; Maria Widmar; Krishna Iyer; Janie Y. Zhang; Nicole Gianino; Christopher H. Crane; Paul B. Romesser; Emmanouil P. Pappou; Philip Paty; Julio García‐Aguilar; Mithat Gönen; Marc J. Gollub; Martin R. Weiser; Kurt A. Schalper; Luis A. Díaz

doi:10.1056/nejmoa2201445

Abstract

Mismatch repair-deficient, locally advanced rectal cancer was highly sensitive to single-agent PD-1 blockade. Longer follow-up is needed to assess the duration of response. (Funded by the Simon and Eve Colin Foundation and others; ClinicalTrials.gov number, NCT04165772.).

Keywords

BlockadeMedicineColorectal cancerOncologyCancerInternal medicine

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Publication Info

Year: 2022
Type: article
Volume: 386
Issue: 25
Pages: 2363-2376
Citations: 1367
Access: Closed

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APA Style

                            
                                
                                    Andrea Cercek, 
                                
                                    Melissa Lumish, 
                                
                                    Jenna Sinopoli
                                
                                et al.
                            
                            (2022). 
                            PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer. 
                            New England Journal of Medicine
                            , 386
                            (25)
                            , 2363-2376.
                            https://doi.org/10.1056/nejmoa2201445
                        

Identifiers

DOI: 10.1056/nejmoa2201445