PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Keywords

BiologyGeneDNA microarrayGene expression profilingGene expressionOxidative phosphorylationGeneticsRegulation of gene expressionComputational biologyBiochemistry

Affiliated Institutions

Related Publications

Significance analysis of microarrays applied to the ionizing radiation response

Virginia Goss Tusher , Robert Tibshirani , Gilbert Chu

Microarrays can measure the expression of thousands of genes to identify changes in expression between different biological states. Methods are needed to determine the significa...

2001 Proceedings of the National Academy o... 10601 citations

Cluster analysis and display of genome-wide expression patterns

Michael B. Eisen , Paul T. Spellman , Patrick O. Brown +1 more

A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according ...

1998 Proceedings of the National Academy o... 16293 citations

Expression Atlas update—an integrated database of gene and protein expression in humans, animals and plants

Robert Petryszak , Maria Keays , Amy Tang +21 more

Expression Atlas (http://www.ebi.ac.uk/gxa) provides information about gene and protein expression in animal and plant samples of different cell types, organism parts, developme...

2015 Nucleic Acids Research 548 citations

The human disease network

K.-I. Goh , Michael E. Cusick , David Valle +3 more

A network of disorders and disease genes linked by known disorder–gene associations offers a platform to explore in a single graph-theoretic framework all known phenotype and di...

2007 Proceedings of the National Academy o... 3182 citations

NCBI GEO: archive for functional genomics data sets--10 years on

Tanya Barrett , D. B. Troup , S. E. Wilhite +12 more

A decade ago, the Gene Expression Omnibus (GEO) database was established at the National Center for Biotechnology Information (NCBI). The original objective of GEO was to serve ...

2010 Nucleic Acids Research 1127 citations

Publication Info

Year: 2003
Type: article
Volume: 34
Issue: 3
Pages: 267-273
Citations: 10172
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

10172

OpenAlex

Cite This

APA Style

                            
                                
                                    Vamsi K. Mootha, 
                                
                                    Cecilia M. Lindgren, 
                                
                                    Karl‐Fredrik Eriksson
                                
                                et al.
                            
                            (2003). 
                            PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. 
                            Nature Genetics
                            , 34
                            (3)
                            , 267-273.
                            https://doi.org/10.1038/ng1180
                        

Identifiers

DOI: 10.1038/ng1180