Whitehead Institute for Biomedical Research

Hallmarks of Cancer: The Next Generation

MicroRNAs

The Hallmarks of Cancer

Initial sequencing and analysis of the human genome

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collabor...

MicroRNAs: Target Recognition and Regulatory Functions

Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or for assigning tumo...

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

The basics of epithelial-mesenchymal transition

The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understoo...

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells