Potentilla freyniana bornm. and its active component tangeretin ameliorate gouty arthritis by inhibiting the MAPK/NF-κb/NLRP3 signaling pathway

Kaiqun Liu; Cong Liu; Chen Wu; Shuhui Lei; Zilu Bao; Chenyang Yu; Min Zou; Xuesong Zhang; Huan Zhang; Huihui Zhang; Wei Li; Rui You; Liqun Wei; Lan Zhang; Dan Liu; Lvyi Chen

doi:10.1016/j.jep.2025.121013

Affiliated Institutions

Hubei University of Chinese Medicine CN

Related Publications

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

Uwe Senftleben , Yixue Cao , Gutian Xiao +8 more

In mammals, the canonical nuclear factor κB (NF-κB) signaling pathway activated in response to infections is based on degradation of IκB inhibitors. This pathway depends on the ...

2001 Science 1342 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

Marta Muzio , Jian Ni , Ping Feng +1 more

The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-κB) activation in mammals and is similar to the Toll pathway in Drosophila : the IL-1R–a...

1997 Science 1155 citations

Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

Helen Le-Niculescu , Emanuela Bonfoco , Yoshitoshi Kasuya +3 more

The JNK pathway modulates AP-1 activity. While in some cells it may have proliferative and protective roles, in neuronal cells it is involved in apoptosis in response to stress ...

1999 Molecular and Cellular Biology 467 citations

The noncanonical NF‐κB pathway

Shao‐Cong Sun

Summary: The noncanonical nuclear factor‐κB (NF‐κB) signaling pathway mediates activation of the p52/RelB NF‐κB complex and, thereby, regulates specific immunological processes....

2012 Immunological Reviews 680 citations

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Hui Yu , Liangbin Lin , Zhiqiang Zhang +2 more

NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is activated by various stimuli, transducing a quick but transient transcriptional activity, ...

2020 Signal Transduction and Targeted Therapy 1817 citations

Publication Info

Year: 2025
Type: article
Volume: 358
Pages: 121013-121013
Citations: 0
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Potentilla freyniana bornm. and its active component tangeretin ameliorate gouty arthritis by inhibiting the MAPK/NF-κb/NLRP3 signaling pathway

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                    Kaiqun Liu, 
                                
                                    Cong Liu, 
                                
                                    Chen Wu
                                
                                et al.
                            
                            (2025). 
                            Potentilla freyniana bornm. and its active component tangeretin ameliorate gouty arthritis by inhibiting the MAPK/NF-κb/NLRP3 signaling pathway. 
                            Journal of Ethnopharmacology
                            , 358
                            
                            , 121013-121013.
                            https://doi.org/10.1016/j.jep.2025.121013

Identifiers

DOI: 10.1016/j.jep.2025.121013