Randomized trials stopped early for benefit: a systematic review.

Abstract

RCTs stopped early for benefit are becoming more common, often fail to adequately report relevant information about the decision to stop early, and show implausibly large treatment effects, particularly when the number of events is small. These findings suggest clinicians should view the results of such trials with skepticism.

Keywords

MedicineRandomized controlled trialInterimInterim analysisSample size determinationPsychological interventionClinical trialMEDLINEIntervention (counseling)Family medicineInternal medicinePsychiatry

Affiliated Institutions

McMaster University CA

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Publication Info

Year: 2005
Type: review
Volume: 294
Issue: 17
Pages: 2203-9
Citations: 687
Access: Closed

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APA Style

                            
                                
                                    Víctor M. Montori, 
                                
                                    P.J. Devereaux, 
                                
                                    Neill K. J. Adhikari
                                
                                et al.
                            
                            (2005). 
                            Randomized trials stopped early for benefit: a systematic review.. 
                            PubMed
                            , 294
                            (17)
                            , 2203-9.
                            https://doi.org/10.1001/jama.294.17.2203
                        

Identifiers

DOI: 10.1001/jama.294.17.2203