Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

Jakob von Moltke; Norver J. Trinidad; Mahtab Moayeri; Alexander F. Kintzer; Samantha B. Wang; Nico van Rooijen; Charles R. Brown; Bryan A. Krantz; Stephen H. Leppla; Karsten Gronert; Russell E. Vance

doi:10.1038/nature11351

Keywords

InflammasomeIn vivoInflammatory responseInflammationLipid signalingChemistryBiologyImmunologyBiotechnology

Affiliated Institutions

Related Publications

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley , Devon Jeltema , Yanhui Duan +1 more

The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in respo...

2019 International Journal of Molecular Sc... 3150 citations

Mechanism of NLRP3 inflammasome activation

Fayyaz S. Sutterwala , Stefanie Haasken , Suzanne L. Cassel

Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen‐ and damage‐assoc...

2014 Annals of the New York Academy of Sci... 715 citations

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

Sarmistha Saha , Brigitta Buttari , Emiliano Panieri +2 more

Inflammation is a key driver in many pathological conditions such as allergy, cancer, Alzheimer’s disease, and many others, and the current state of available drugs prompted res...

2020 Molecules 1178 citations

Oxidized phospholipids as modulators of inflammation in atherosclerosis

Norbert Leitinger

During inflammatory processes biologically active lipid oxidation products accumulate that modulate the inflammatory process and may determine the fate and outcome of the body's...

2003 Current Opinion in Lipidology 289 citations

THE INFLUENCE OF REVERSIBLE OXYGEN BINDING ON THE INTERACTION BETWEEN HEMOGLOBIN SUBMITS

R Benesch , R Benesch , Miranda Williamson

Fast, low-cost, accurate detection of time-resolved dynamic nucleic acid conformational variation in response to small molecule binding: 1) enriches our understanding of nucleic...

1962 Proceedings of the National Academy o... 48 citations

Publication Info

Year: 2012
Type: article
Volume: 490
Issue: 7418
Pages: 107-111
Citations: 437
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

437

OpenAlex

Cite This

APA Style

                            
                                
                                    Jakob von Moltke, 
                                
                                    Norver J. Trinidad, 
                                
                                    Mahtab Moayeri
                                
                                et al.
                            
                            (2012). 
                            Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. 
                            Nature
                            , 490
                            (7418)
                            , 107-111.
                            https://doi.org/10.1038/nature11351
                        

Identifiers

DOI: 10.1038/nature11351