Recommendations for Improving Serum Creatinine Measurement: A Report from the Laboratory Working Group of the National Kidney Disease Education Program

Abstract

The current variability in serum creatinine measurements renders all estimating equations for GFR, including the MDRD Study equation, less accurate in the normal and slightly increased range of serum creatinine concentrations [<133 micromol/L (1.5 mg/dL)], which is the relevant range for detecting CKD [<60 mL.min(-1).(1.73 m2)(-1)]. Many automated routine methods for serum creatinine measurement meet or exceed the required precision; therefore, reduction of analytical bias in creatinine assays is needed. Standardization of calibration does not correct for analytical interferences (nonspecificity bias). The bias and nonspecificity problems associated with some of the routine methods must be addressed.

Keywords

Affiliated Institutions

• Virginia Commonwealth University US
• Cleveland Clinic US
• Luigi Sacco Hospital IT
• Leco Corporation (United States) US
• Tufts University US
• National Institute of Standards and Technology US
• University of Minnesota US
• Johns Hopkins University US
• Johnson & Johnson (United States) US
• National Institute of Standards EG
• National Institutes of Health US

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