Restoration of TGF-β signalling reduces tumorigenicity in human lung cancer cells

Govindaraj Anumanthan; S. Halder; Hiroyuki Osada; Takashi Takahashi; Pierre P. Massion; David P. Carbone; Pran K. Datta

doi:10.1038/sj.bjc.6602831

Keywords

BiologyCell growthCell cultureMolecular biologyApoptosisDownregulation and upregulationLung cancerGene expressionInternal medicineBiochemistryGeneMedicineGenetics

Affiliated Institutions

Related Publications

TGF-β SIGNAL TRANSDUCTION

Joan Massagué

The transforming growth factor β (TGF-β) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has...

1998 Annual Review of Biochemistry 7550 citations

Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression

Sadegh Saghafinia , Krisztián Homicskó , Annunziata Di Domenico +6 more

Abstract Pancreatic neuroendocrine tumors (PanNET) comprise two molecular subtypes, relatively benign islet tumors (IT) and invasive, metastasis-like primary (MLP) tumors. Until...

2021 Cancer Discovery 45 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

Daniel A. Rappolee , Mark David , Michael J. Banda +1 more

The presence of macrophages is required for the regeneration of many cell types during wound healing. Macrophages have been reported to express a wide range of mitogenic factors...

1988 Science 1104 citations

Transforming Growth Factor-β Signaling in Immunity and Cancer

Eduard Batlle , Joan Massagué

Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system...

2019 Immunity 2114 citations

MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents

Dawn R. Cochrane , Nicole S. Spoelstra , Erin N. Howe +2 more

Abstract The transcription factor ZEB1 is normally not expressed in epithelial cells. When inappropriately expressed in carcinomas, ZEB1 initiates epithelial to mesenchymal tran...

2009 Molecular Cancer Therapeutics 312 citations

Publication Info

Year: 2005
Type: article
Volume: 93
Issue: 10
Pages: 1157-1167
Citations: 64
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Restoration of TGF-β signalling reduces tumorigenicity in human lung cancer cells

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                
                                    Govindaraj Anumanthan, 
                                
                                    S. Halder, 
                                
                                    Hiroyuki Osada
                                
                                et al.
                            
                            (2005). 
                            Restoration of TGF-β signalling reduces tumorigenicity in human lung cancer cells. 
                            British Journal of Cancer
                            , 93
                            (10)
                            , 1157-1167.
                            https://doi.org/10.1038/sj.bjc.6602831
                        

Identifiers

DOI: 10.1038/sj.bjc.6602831