Abstract
The transforming growth factor β (TGF-β) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-β signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners. Distinct repertoires of receptors, SMAD proteins, and DNA-binding partners seemingly underlie, in a cell-specific manner, the multifunctional nature of TGF-β and related factors. Mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
Keywords
Signal transductionTransduction (biophysics)R-SMADTransforming growth factorCell biologyBiologyGeneticsReceptorBiochemistryGrowth factorTGF alpha
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Publication Info
- Year
- 1998
- Type
- review
- Volume
- 67
- Issue
- 1
- Pages
- 753-791
- Citations
- 7550
- Access
- Closed
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Cite This
Joan Massagué
(1998).
TGF-β SIGNAL TRANSDUCTION.
Annual Review of Biochemistry
, 67
(1)
, 753-791.
https://doi.org/10.1146/annurev.biochem.67.1.753
Identifiers
- DOI
- 10.1146/annurev.biochem.67.1.753