RNA-binding proteins in human genetic disease

Fátima Gebauer; Thomas Schwarzl; Juan Valcárcel; Matthias W. Hentze

doi:10.1038/s41576-020-00302-y

Keywords

RNA-binding proteinBiologyComputational biologyRNAEffectorRegulation of gene expressionGene expressionGeneGeneticsCell biology

Affiliated Institutions

Related Publications

A brave new world of RNA-binding proteins

Matthias W. Hentze , Alfredo Castelló , Thomas Schwarzl +1 more

RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding domains (RBDs) and change the fate or function of the...

2018 Nature Reviews Molecular Cell Biology 1775 citations

Regulation of mRNA Translation and Stability by microRNAs

Marc R. Fabian , Nahum Sonenberg , Witold Filipowicz

MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base-pai...

2010 Annual Review of Biochemistry 3219 citations

doRiNA: a database of RNA interactions in post-transcriptional regulation

Gerd Anders , Sebastian D. Mackowiak , Marvin Jens +5 more

In animals, RNA binding proteins (RBPs) and microRNAs (miRNAs) post-transcriptionally regulate the expression of virtually all genes by binding to RNA. Recent advances in experi...

2011 Nucleic Acids Research 207 citations

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang , Hengyou Weng , Wenju Sun +27 more

N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to re...

2018 Nature Cell Biology 2907 citations

DNA polymerase of bacteriophage T4 is an autogenous translational repressor.

Mark Andrake , Nancy Guild , Tien Hsu +3 more

In bacteriophage T4 the protein product of gene 43 (gp43) is a multifunctional DNA polymerase that is essential for replication of the phage genome. The protein harbors DNA-bind...

1988 Proceedings of the National Academy o... 63 citations

Publication Info

Year: 2020
Type: review
Volume: 22
Issue: 3
Pages: 185-198
Citations: 1194
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

RNA-binding proteins in human genetic disease

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1194

OpenAlex

Cite This

APA Style

                            
                                
                                    Fátima Gebauer, 
                                
                                    Thomas Schwarzl, 
                                
                                    Juan Valcárcel
                                
                                et al.
                            
                            (2020). 
                            RNA-binding proteins in human genetic disease. 
                            Nature Reviews Genetics
                            , 22
                            (3)
                            , 185-198.
                            https://doi.org/10.1038/s41576-020-00302-y
                        

Identifiers

DOI: 10.1038/s41576-020-00302-y