Keywords
BiologyMolecular biologyRNARIG-IDNARNA-dependent RNA polymerasePolymeraseRNA polymerase IIIRNA polymeraseInterferonBiochemistryGeneVirology
Affiliated Institutions
Related Publications
A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA
The activation of the innate immune responses by DNA exposed within the cytosol has gained much attention and, in this context, several cytosolic DNA sensors have been identifie...
Toll‐like Receptor and RIG‐1‐like Receptor Signaling
Toll‐like receptors (TLRs) and RIG‐I‐like receptors (RLRs) constitute distinct families of pattern‐recognition receptors that sense nucleic acids derived from viruses and trigge...
RIG-I-like receptors: their regulation and roles in RNA sensing
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes th...
RNA recognition and signal transduction by RIG‐I‐like receptors
Summary: Viral infection is detected by cellular sensor molecules as foreign nucleic acids and initiates innate antiviral responses, including the activation of proinflammatory ...
HOW CELLS RESPOND TO INTERFERONS
Interferons play key roles in mediating antiviral and antigrowth responses and in modulating immune response. The main signaling pathways are rapid and direct. They involve tyro...
Publication Info
- Year
- 2009
- Type
- article
- Volume
- 138
- Issue
- 3
- Pages
- 576-591
- Citations
- 1141
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1141
OpenAlex
Cite This
Yu‐Hsin Chiu,
John B. MacMillan,
Zhijian J. Chen
(2009).
RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway.
Cell
, 138
(3)
, 576-591.
https://doi.org/10.1016/j.cell.2009.06.015
Identifiers
- DOI
- 10.1016/j.cell.2009.06.015