Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

2021 New England Journal of Medicine 1,301 citations

Abstract

Progression-free and overall survival were significantly longer with sacituzumab govitecan than with single-agent chemotherapy among patients with metastatic triple-negative breast cancer. Myelosuppression and diarrhea were more frequent with sacituzumab govitecan. (Funded by Immunomedics; ASCENT ClinicalTrials.gov number, NCT02574455; EudraCT number, 2017-003019-21.).

Keywords

MedicineInternal medicineHazard ratioVinorelbineMetastatic breast cancerOncologyBreast cancerChemotherapyEribulinGemcitabineCancerGastroenterologySurgeryConfidence interval

Affiliated Institutions

Related Publications

Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial

Pembrolizumab monotherapy showed durable antitumour activity and manageable safety in patients with metastatic triple-negative breast cancer. We aimed to examine whether the add...

2020 The Lancet 1658 citations

Publication Info

Year
2021
Type
article
Volume
384
Issue
16
Pages
1529-1541
Citations
1301
Access
Closed

External Links

Social Impact

Social media, news, blog, policy document mentions

Citation Metrics

1301
OpenAlex

Cite This

Aditya Bardia, Sara A. Hurvitz, Sara M. Tolaney et al. (2021). Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer. New England Journal of Medicine , 384 (16) , 1529-1541. https://doi.org/10.1056/nejmoa2028485

Identifiers

DOI
10.1056/nejmoa2028485