Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

Dunyaporn Trachootham; Yan Zhou; Hui Zhang; Yusuke Demizu; Chen Zhao; Hélène Pelicano; Paul J. Chiao; Geetha Achanta; Ralph B. Arlinghaus; Jinsong Liu; Peng Huang

doi:10.1016/j.ccr.2006.08.009

Keywords

Phenethyl isothiocyanateReactive oxygen speciesProgrammed cell deathCell biologyCancer cellBiologyApoptosisCell growthIsothiocyanateMitochondrial ROSCancer researchChemistryCancerBiochemistry

Affiliated Institutions

Related Publications

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

Thomas M. Johnson , Zu‐Xi Yu , V J Ferrans +2 more

Reactive oxygen species (ROS) have been implicated as potential modulators of apoptosis. Conversely, experiments under hypoxic conditions have suggested that apoptosis could occ...

1996 Proceedings of the National Academy o... 585 citations

Free Radicals in the Physiological Control of Cell Function

Wulf Dröge

At high concentrations, free radicals and radical-derived, nonradical reactive species are hazardous for living organisms and damage all major cellular constituents. At moderate...

2002 Physiological Reviews 9689 citations

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

Ying Wang , Robyn Branicky , Alycia Noë +1 more

Superoxide dismutases (SODs) are universal enzymes of organisms that live in the presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen peroxide...

2018 The Journal of Cell Biology 1932 citations

Signal transduction by reactive oxygen species

Toren Finkel

Although historically viewed as purely harmful, recent evidence suggests that reactive oxygen species (ROS) function as important physiological regulators of intracellular signa...

2011 The Journal of Cell Biology 2225 citations

Heat stress induces ferroptosis-like cell death in plants

Ayelén Mariana Distéfano , María Victoria Martin , Juan Pablo Córdoba +11 more

In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iro...

2017 The Journal of Cell Biology 246 citations

Publication Info

Year: 2006
Type: article
Volume: 10
Issue: 3
Pages: 241-252
Citations: 1066
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1066

OpenAlex

Cite This

APA Style

                            
                                
                                    Dunyaporn Trachootham, 
                                
                                    Yan Zhou, 
                                
                                    Hui Zhang
                                
                                et al.
                            
                            (2006). 
                            Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate. 
                            Cancer Cell
                            , 10
                            (3)
                            , 241-252.
                            https://doi.org/10.1016/j.ccr.2006.08.009
                        

Identifiers

DOI: 10.1016/j.ccr.2006.08.009