Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Keywords

BiologyGeneticsGeneSingle-nucleotide polymorphismChromosomeGenome-wide association studyGenetic associationGenomeAutophagyReplication (statistics)GenotypeVirology

Affiliated Institutions

Related Publications

The Genotype-Tissue Expression (GTEx) project.

John T. Lonsdale , Jeffrey Thomas , Mike Salvatore +97 more

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain un...

2013 PubMed 9436 citations

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Laura J. Scott , Karen L. Mohlke , Lori L. Bonnycastle +38 more

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genot...

2007 Science 2757 citations

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Paul R. Burton , David Clayton , Lon R. Cardon +97 more

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We descri...

2007 Nature 9552 citations

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

Richa Saxena , Benjamin F. Voight , Valeriya Lyssenko +64 more

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (...

2007 Science 2875 citations

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Eleftheria Zeggini , Michael N. Weedon , Cecilia M. Lindgren +23 more

The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 populatio...

2007 Science 2195 citations

Publication Info

Year: 2007
Type: article
Volume: 39
Issue: 7
Pages: 830-832
Citations: 1150
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1150

OpenAlex

Cite This

APA Style

                            
                                
                                    Miles Parkes, 
                                
                                    Jeffrey C. Barrett, 
                                
                                    Natalie J. Prescott
                                
                                et al.
                            
                            (2007). 
                            Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. 
                            Nature Genetics
                            , 39
                            (7)
                            , 830-832.
                            https://doi.org/10.1038/ng2061
                        

Identifiers

DOI: 10.1038/ng2061