Western General Hospital

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We descri...

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, ...

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis

Discovery and refinement of loci associated with lipid levels

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for c...

A reference panel of 64,976 haplotypes for genotype imputation

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Hundreds of variants clustered in genomic loci and biological pathways affect human height