Sequence Variations in <i>PCSK9,</i> Low LDL, and Protection against Coronary Heart Disease

Abstract

These data indicate that moderate lifelong reduction in the plasma level of LDL cholesterol is associated with a substantial reduction in the incidence of coronary events, even in populations with a high prevalence of non-lipid-related cardiovascular risk factors.

Keywords

PCSK9MedicineInternal medicineCardiologyHazard ratioMyocardial infarctionCholesterolEvolocumabIncidence (geometry)Confidence intervalPopulationAlirocumabEndocrinologyLipoproteinLDL receptorApolipoprotein A1

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Publication Info

Year: 2006
Type: article
Volume: 354
Issue: 12
Pages: 1264-1272
Citations: 3106
Access: Closed

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APA Style

                            
                                
                                    Jonathan C. Cohen, 
                                
                                    Eric Boerwinkle, 
                                
                                    Thomas H. Mosley
                                
                                et al.
                            
                            (2006). 
                            Sequence Variations in <i>PCSK9,</i> Low LDL, and Protection against Coronary Heart Disease. 
                            New England Journal of Medicine
                            , 354
                            (12)
                            , 1264-1272.
                            https://doi.org/10.1056/nejmoa054013
                        

Identifiers

DOI: 10.1056/nejmoa054013