Center for Human Genetics

PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

The organization of the human cerebral cortex estimated by intrinsic functional connectivity

Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relation...

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

The gene-expression profile we studied is a more powerful predictor of the outcome of disease in young patients with breast cancer than standard systems based on clinical and hi...

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly d...

Sequence Variations in <i>PCSK9,</i> Low LDL, and Protection against Coronary Heart Disease

These data indicate that moderate lifelong reduction in the plasma level of LDL cholesterol is associated with a substantial reduction in the incidence of coronary events, even ...

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (...

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease