Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

Peter van Galen; Volker Hovestadt; Marc H. Wadsworth; Travis K. Hughes; Gabriel K. Griffin; Sofia Battaglia; Julia A. Verga; Jason Stephansky; Timothy J. Pastika; Jennifer Lombardi Story; Geraldine S. Pinkus; Olga Pozdnyakova; Ilene Galinsky; Richard M. Stone; Timothy A. Graubert; Alex K. Shalek; Jon C. Aster; Andrew A. Lane; B Bernstein

doi:10.1016/j.cell.2019.01.031

Keywords

BiologyRNA-SeqImmunityDiseaseRNAComputational biologyGeneticsCellTranscriptomeGeneImmune systemGene expression

Affiliated Institutions

Related Publications

Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding

Alexander Rosenberg , Charles M. Roco , Richard A. Muscat +11 more

Identifying single-cell types in the mouse brain The recent development of single-cell genomic techniques allows us to profile gene expression at the single-cell level easily, a...

2018 Science 1424 citations

Mapping the Mouse Cell Atlas by Microwell-Seq

Xiaoping Han , Renying Wang , Yincong Zhou +25 more

Single-cell RNA sequencing (scRNA-seq) technologies are poised to reshape the current cell-type classification system. However, a transcriptome-based single-cell atlas has not b...

2018 Cell 1628 citations

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Elham Azizi , Ambrose Carr , George Plitas +16 more

Knowledge of immune cell phenotypes in the tumor microenvironment is essential for understanding mechanisms of cancer progression and immunotherapy response. We profiled 45,000 ...

2018 Cell 1993 citations

Spatial reconstruction of single-cell gene expression data

Rahul Satija , Jeffrey A. Farrell , David Gennert +2 more

Spatial localization is a key determinant of cellular fate and behavior, but methods for spatially resolved, transcriptome-wide gene expression profiling across complex tissues ...

2015 Nature Biotechnology 6934 citations

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Cole Trapnell , Davide Cacchiarelli , Jonna Grimsby +7 more

Defining the transcriptional dynamics of a temporal process such as cell differentiation is challenging owing to the high variability in gene expression between individual cells...

2014 Nature Biotechnology 7128 citations

Publication Info

Year: 2019
Type: article
Volume: 176
Issue: 6
Pages: 1265-1281.e24
Citations: 1083
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1083

OpenAlex

Cite This

APA Style

                            
                                
                                    Peter van Galen, 
                                
                                    Volker Hovestadt, 
                                
                                    Marc H. Wadsworth
                                
                                et al.
                            
                            (2019). 
                            Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity. 
                            Cell
                            , 176
                            (6)
                            , 1265-1281.e24.
                            https://doi.org/10.1016/j.cell.2019.01.031
                        

Identifiers

DOI: 10.1016/j.cell.2019.01.031