Abstract
It is suggested that most childhood acute lymphoblastic leukaemias and some other paediatric cancers are chemo-curable because they arise in stem cell populations that are functionally transient, chemosensitive and programmed for apoptosis. Most adult acute leukaemias are chemo-incurable at least in part because they originate in relatively drug resistant stem cells with extensive self-renewal capacity. The latter property in turn increases the probability of clones evolving with multi-drug resistance. Particular mutations may superimpose additional adverse features on leukaemic cells.
Keywords
Stem cellCancer researchDrug resistanceMedicineBiologyGenetics
MeSH Terms
AdultApoptosisChildHumansLeukemiaMyelogenousChronicBCR-ABL PositivePhenotypePrecursor Cell Lymphoblastic Leukemia-LymphomaStem Cells
Affiliated Institutions
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Publication Info
- Year
- 1993
- Type
- article
- Volume
- 67
- Issue
- 3
- Pages
- 413-423
- Citations
- 88
- Access
- Closed
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Cite This
MF Greaves
(1993).
Stem cell origins of leukaemia and curability.
British Journal of Cancer
, 67
(3)
, 413-423.
https://doi.org/10.1038/bjc.1993.81
Identifiers
- DOI
- 10.1038/bjc.1993.81
- PMID
- 8439493
- PMCID
- PMC1968264