Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Abstract

A wrench in the works of COVID-19 Understanding the inner workings of the virus that causes coronavirus disease 2019 (COVID-19) may help us to disrupt it. Yin et al. focused on the viral polymerase essential for replicating viral RNA. They determined a structure of the polymerase bound to RNA and to the drug remdesivir. Remdesivir mimics an RNA nucleotide building block and is covalently linked to the replicating RNA, which blocks further synthesis of RNA. The structure provides a template for designing improved therapeutics against the viral polymerase. Science , this issue p. 1499

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Affiliated Institutions

• University of Chinese Academy of Sciences CN
• Chinese Academy of Sciences CN
• Tsinghua University CN
• Shanghai Institute of Materia Medica CN
• Sir Run Run Shaw Hospital CN
• Center for Life Sciences CN
• Biortus (China) CN
• Zhejiang University CN
• Shanghai Jiao Tong University CN
• Chinese Academy of Medical Sciences & Peking Union Medical College CN
• Peking Union Medical College Hospital CN

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