Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

Keywords

Virtual screeningDrugAntiviral drugDrug discoveryCoronavirusIndinavirPharmacologyDrug repositioningDruggabilityComputational biologyMedicineVirologyCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)BiologyBioinformaticsViral loadDiseaseVirusBiochemistryAntiretroviral therapyGeneInternal medicine

Affiliated Institutions

Related Publications

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

David E. Gordon , Gwendolyn Μ. Jang , Mehdi Bouhaddou +97 more

2020 Nature 4709 citations

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann , Hannah Kleine‐Weber , Simon Schroeder +10 more

The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry...

2020 Cell 20901 citations

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu , Hua Guo , Peng Zhou +1 more

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute re...

2020 Nature Reviews Microbiology 5269 citations

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Manli Wang , Ruiyuan Cao , Leike Zhang +7 more

Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were l...

2020 Cell Research 7255 citations

SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients

Lirong Zou , Feng Ruan , Mingxing Huang +13 more

SARS-CoV-2 Viral Load in Upper Respiratory Specimens The authors report results of an analysis of nasal and throat swabs from 17 patients in Zhuhai, China, who had received a di...

2020 New England Journal of Medicine 5136 citations

Publication Info

Year: 2020
Type: article
Volume: 582
Issue: 7811
Pages: 289-293
Citations: 4341
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

4341

OpenAlex

Cite This

APA Style

                            
                                
                                    Zhenming Jin, 
                                
                                    Xiaoyu Du, 
                                
                                    Yechun Xu
                                
                                et al.
                            
                            (2020). 
                            Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. 
                            Nature
                            , 582
                            (7811)
                            , 289-293.
                            https://doi.org/10.1038/s41586-020-2223-y
                        

Identifiers

DOI: 10.1038/s41586-020-2223-y