Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion

Abstract

Stimulated rat peritoneal neutrophils release a platelet inhibitory factor with the pharmacological properties of NO. This release is inhibited by NG-monomethyl-L-arginine and L-canavanine, indicating that it occurs through a mechanism similar to that in vascular endothelial cells and macrophages. As the degree of stimulation increases, the factor released is progressively inactivated by concomitant release of superoxide anions.

Keywords

SuperoxideNitric oxideArginineChemistryPlateletBiochemistryPlatelet-activating factorStimulationBiologyImmunologyEnzymeEndocrinologyAmino acid

Affiliated Institutions

Wellcome Trust GB

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Publication Info

Year: 1989
Type: article
Volume: 261
Issue: 1
Pages: 293-296
Citations: 520
Access: Closed

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APA Style

                            
                                
                                    Thérèse McCall, 
                                
                                    N. K. Boughton-Smith, 
                                
                                    Richard Palmer
                                
                                et al.
                            
                            (1989). 
                            Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion. 
                            Biochemical Journal
                            , 261
                            (1)
                            , 293-296.
                            https://doi.org/10.1042/bj2610293
                        

Identifiers

DOI: 10.1042/bj2610293