Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Prabhu S. Arunachalam , Florian Wimmers , Chris Ka Pun Mok , Prabhu S. Arunachalam , Florian Wimmers , Chris Ka Pun Mok , Ranawaka A. P. M. Perera , Madeleine Scott , Thomas Hagan , Natalia Sigal , Yupeng Feng , Laurel Bristow , Owen Tak‐Yin Tsang , Dhananjay Wagh , John A. Coller , Kathryn L. Pellegrini , Dmitri Kazmin , Ghina Alaaeddine , Wai-Shing Leung , Jacky Man Chun Chan , Thomas Shiu Hong Chik , Chris Yau Chung Choi , Christopher Huerta , Michele Paine McCullough , Huibin Lv , Evan J. Anderson , Srilatha Edupuganti , Amit A. Upadhyay , Steve Bosinger , Holden T. Maecker , Purvesh Khatri , Nadine Rouphael , Malik Peiris , Bali Pulendran
2020 Science 1,291 citations

Abstract

Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam et al. report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These studies provide a compendium of immune cell information and roadmaps for potential therapeutic interventions. Science , this issue p. eabc8511 , p. 1210

Keywords

Coronavirus disease 2019 (COVID-19)ImmunitySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakVirologyBetacoronavirusBiologyImmunologyMedicineImmune systemInternal medicineInfectious disease (medical specialty)OutbreakDisease

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Year
2020
Type
article
Volume
369
Issue
6508
Pages
1210-1220
Citations
1291
Access
Closed

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Prabhu S. Arunachalam, Florian Wimmers, Chris Ka Pun Mok et al. (2020). Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans. Science , 369 (6508) , 1210-1220. https://doi.org/10.1126/science.abc6261

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DOI
10.1126/science.abc6261