Abstract

Poly(glycolic acid) (PGA) has long been a popular polymer in the tissue engineering field. PGA possesses many favorable properties such as biocompatibility, bioabsorbability, and tensile strength. The traditional fiber formation techniques of melt extrusion and cold-drawing are generally limited to fibers of 10–12 μm in diameter. Electrostatic spinning, or electrospinning, is an attractive approach for the production of much smaller diameter fibers which are of interest as tissue engineering scaffolds. We demonstrate the ability to control the fiber diameter of PGA as a function of solution concentration and fiber orientation, as well as show a correlation between the fiber orientation, elastic modulu, and strain to failure of PGA in a uniaxial model.

Keywords

ElectrospinningTissue engineeringMaterials scienceBiocompatibilityUltimate tensile strengthSpinningExtrusionComposite materialFiberGlycolic acidPolymerBiomedical engineeringLactic acid

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Publication Info

Year
2001
Type
article
Volume
38
Issue
12
Pages
1231-1243
Citations
456
Access
Closed

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Eugene D. Boland, Gary E. Wnek, David Simpson et al. (2001). TAILORING TISSUE ENGINEERING SCAFFOLDS USING ELECTROSTATIC PROCESSING TECHNIQUES: A STUDY OF POLY(GLYCOLIC ACID) ELECTROSPINNING. Journal of Macromolecular Science Part A , 38 (12) , 1231-1243. https://doi.org/10.1081/ma-100108380

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DOI
10.1081/ma-100108380