Abstract

Localization in tissues and migration to lymphoid organs are essential steps in the immunobiology of dendritic cells (DC). Chemokines play an important role in guiding the traffic of DC. Receptor expression and responsiveness to constitutively made chemokines account for the presence of DC in normal tissues. Inflammatory chemokines and non-chemokine attractants promote recruitment and localization of DC at sites of inflammation and infection. During maturation, DC undergo a profound and orderly rearrangement of their chemokine receptor repertoire. The chemokine receptor switch paradigm provides a conceptual framework for the complex migration of DC in vivo, including their recruitment and positioning in tumor tissues.

Keywords

ChemokineChemokine receptorBiologyCCR1CCL21Cell biologyDendritic cellCXC chemokine receptorsCC chemokine receptorsImmunologyInflammationC-C chemokine receptor type 7CCL7Immune system

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Year
2000
Type
review
Volume
177
Issue
1
Pages
141-149
Citations
174
Access
Closed

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Paola Allavena, Antonio Sica, Annunciata Vecchi et al. (2000). The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues. Immunological Reviews , 177 (1) , 141-149. https://doi.org/10.1034/j.1600-065x.2000.17714.x

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DOI
10.1034/j.1600-065x.2000.17714.x