The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists

Da Wei Huang; Brad T. Sherman; Qina Tan; Jack Collins; W. Gregory Alvord; Jean Roayaei; Robert D. Stephens; Michael Baseler; H. Clifford Lane; Richard A. Lempicki

doi:10.1186/gb-2007-8-9-r183

Abstract

Abstract The DAVID Gene Functional Classification Tool http://david.abcc.ncifcrf.gov uses a novel agglomeration algorithm to condense a list of genes or associated biological terms into organized classes of related genes or biology, called biological modules. This organization is accomplished by mining the complex biological co-occurrences found in multiple sources of functional annotation. It is a powerful method to group functionally related genes and terms into a manageable number of biological modules for efficient interpretation of gene lists in a network context.

Keywords

BiologyGeneComputational biologyAnnotationContext (archaeology)Biological networkHuman geneticsGene AnnotationGene regulatory networkGene nomenclatureGeneticsGenomeGene expressionTaxonomy (biology)Nomenclature

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Publication Info

Year: 2007
Type: article
Volume: 8
Issue: 9
Pages: R183-R183
Citations: 2476
Access: Closed

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APA Style

                            
                                
                                    Da Wei Huang, 
                                
                                    Brad T. Sherman, 
                                
                                    Qina Tan
                                
                                et al.
                            
                            (2007). 
                            The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists. 
                            Genome biology
                            , 8
                            (9)
                            , R183-R183.
                            https://doi.org/10.1186/gb-2007-8-9-r183
                        

Identifiers

DOI: 10.1186/gb-2007-8-9-r183