The endothelial glycocalyx: composition, functions, and visualization

Sietze Reitsma; Dick W. Slaaf; Hans Vink; Marc A. M. J. van Zandvoort; Mirjam G.A. oude Egbrink

doi:10.1007/s00424-007-0212-8

Keywords

GlycocalyxEndotheliumCell biologyMechanotransductionGlycobiologyMicrocirculationChemistryBiologyGlycoproteinMedicineGlycanBiochemistryInternal medicine

Affiliated Institutions

Maastricht University NL

Related Publications

Vasculoprotective properties of the endothelial glycocalyx: effects of fluid shear stress

Mirella Gouverneur , Bernard M. van den Berg , Max Nieuwdorp +2 more

Abstract. The endothelial glycocalyx exerts a wide array of vasculoprotective effects via inhibition of coagulation and leucocyte adhesion, by contributing to the vascular perme...

2006 Journal of Internal Medicine 186 citations

Mechanotransduction and the glycocalyx

John M. Tarbell , Manolis Y. Pahakis

Abstract. Endothelial cells (ECs) line all blood vessel walls and are exposed to the mechanical forces of blood flow which modulate their function and play a role in vascular re...

2006 Journal of Internal Medicine 411 citations

Shedding of the Endothelial Glycocalyx in Patients Undergoing Major Vascular Surgery With Global and Regional Ischemia

Markus Rehm , Dirk Bruegger , F. Christ +9 more

Background— The astonishing thickness of the endothelial glycocalyx, which rivals that of endothelial cells in the microvasculature, was disclosed in the last 15 years. As alrea...

2007 Circulation 644 citations

Hypoxia induced disruption of the cardiac endothelial glycocalyx: implications for capillary permeability

Barbara J. Ward , John L. Donnelly

The endothelial cell glycocalyx of continuous capillaries is sensitive to changes in PO2. The disruption of this surface coat may explain the reported increase in capillary perm...

1993 Cardiovascular Research 80 citations

The Structure and Function of the Endothelial Glycocalyx Layer

Sheldon Weinbaum , John M. Tarbell , Edward R. Damiano

Over the past decade, since it was first observed in vivo, there has been an explosion in interest in the thin (∼500 nm), gel-like endothelial glycocalyx layer (EGL) that coats ...

2007 Annual Review of Biomedical Engineering 1133 citations

Publication Info

Year: 2007
Type: review
Volume: 454
Issue: 3
Pages: 345-359
Citations: 1856
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The endothelial glycocalyx: composition, functions, and visualization

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1856

OpenAlex

Cite This

APA Style

                            
                                
                                    Sietze Reitsma, 
                                
                                    Dick W. Slaaf, 
                                
                                    Hans Vink
                                
                                et al.
                            
                            (2007). 
                            The endothelial glycocalyx: composition, functions, and visualization. 
                            Pflügers Archiv - European Journal of Physiology
                            , 454
                            (3)
                            , 345-359.
                            https://doi.org/10.1007/s00424-007-0212-8
                        

Identifiers

DOI: 10.1007/s00424-007-0212-8