Abstract

The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.

Keywords

GeneticsGenetic linkageBiologyChromosomeFamilial adenomatous polyposisAdenomatous polyposis coliGeneLinkage (software)Genetic markerGene mappingChromosome 9Gene mapLong armColorectal cancerCancer

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Publication Info

Year
1987
Type
article
Volume
238
Issue
4832
Pages
1411-1413
Citations
676
Access
Closed

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M. Leppert, M. Dobbs, Peter Scambler et al. (1987). The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5. Science , 238 (4832) , 1411-1413. https://doi.org/10.1126/science.3479843

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DOI
10.1126/science.3479843