Rudolph E. Tanzi

The Genetics of Alzheimer Disease: Back to the Future

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several families have been described in which Alzheimer's disease is caused by an autosomal ...

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

A polymorphic DNA marker genetically linked to Huntington's disease

DNA Markers for Nervous System Diseases

Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identi...

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

The amyloid β protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary...

The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene

Genetic linkage map of human chromosome 21