Abstract
Cancerous growth often results from an increased rate of cell proliferation caused by the abnormal activation of a signal transduction pathway that normally stimulates cell division only in response to growth factor signals; many of the proto-oncogenes that have been characterized function in or respond to such intercellular signaling pathways (for review, see Cooper 1990). Recent findings indicate that cancerous growth also can result from a decreased rate of cell loss. The most striking example is provided by human B-cell follicular lymphomas. These cancers are often associated with t(14;18) chromosomal translocations that cause the proto-oncogene bcl-2 (bcl, B cell lymphoma), normally located on chromosome 18, to be adjacent to and regulated by an enhancer of the immunoglobulin heavy-chain locus, normally located on chromosome 14 (Bakhshi et al. 1985; Cleary and Sklar 1985; Tsujimoto et al. 1985). The resulting overexpression of a normal Bcl-2 protein in the B-cell lineage leads to...
Keywords
BiologyChromosomal translocationCell divisionSignal transductionCaenorhabditis elegansGeneticsLocus (genetics)Proto-OncogenesEnhancerCellCell growthFollicular lymphomaCell biologyLymphomaCancer researchOncogeneTranscription factorGeneCell cycleImmunology
Affiliated Institutions
Related Publications
8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with <i>MYC</i>
The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In th...
BCL-6 EXPRESSION IN REACTIVE LYMPHOID TISSUE AND IN B-CELL NON-HODGKIN'S LYMPHOMAS
Chromosomal abnormalities involving 3q27 have recently been associated with diffuse large B-cell lymphomas and, less frequently, with follicular lymphomas. Molecular studies hav...
Sequencing the <i>erb</i> A Gene of Avian Erythroblastosis Virus Reveals a New Type of Oncogene
Avian erythroblastosis virus (AEV) contains two distinct oncogenes, erb A and erb B. The erb B oncogene, which is homologous to a portion of the epidermal growth factor receptor...
Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression.
B chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of slow-dividing and long-lived monoclonal B cells arrested at the intermediate stage of their differ...
Chromosome Conformation Capture Carbon Copy (5C): A massively parallel solution for mapping interactions between genomic elements
Physical interactions between genetic elements located throughout the genome play important roles in gene regulation and can be identified with the Chromosome Conformation Captu...
Publication Info
- Year
- 1994
- Type
- review
- Volume
- 59
- Issue
- 0
- Pages
- 377-385
- Citations
- 192
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
192
OpenAlex
Cite This
H. Robert Horvitz,
Shai Shaham,
Michael O. Hengartner
(1994).
The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans.
Cold Spring Harbor Symposia on Quantitative Biology
, 59
(0)
, 377-385.
https://doi.org/10.1101/sqb.1994.059.01.042
Identifiers
- DOI
- 10.1101/sqb.1994.059.01.042