The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

Abstract

Abstract Since the publication of the Revised European-American Classification of Lymphoid Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have been generated through iterative international efforts to achieve broad consensus among hematopathologists, geneticists, molecular scientists, and clinicians. Significant progress has recently been made in the characterization of malignancies of the immune system, with many new insights provided by genomic studies. They have led to this proposal. We have followed the same process that was successfully used for the third and fourth editions of the World Health Organization Classification of Hematologic Neoplasms. The definition, recommended studies, and criteria for the diagnosis of many entities have been extensively refined. Some categories considered provisional have now been upgraded to definite entities. Terminology for some diseases has been revised to adapt nomenclature to the current knowledge of their biology, but these modifications have been restricted to well-justified situations. Major findings from recent genomic studies have impacted the conceptual framework and diagnostic criteria for many disease entities. These changes will have an impact on optimal clinical management. The conclusions of this work are summarized in this report as the proposed International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors.

Keywords

Affiliated Institutions

• Centre Hospitalier Universitaire de Lille FR
• Université Paris Cité FR
• Harvard University US
• Assistance Publique – Hôpitaux de Paris FR
• Istituto di Ematologia di Bologna IT
• University Hospital of Basel CH
• Institut universitaire du cancer de Toulouse Oncopole FR
• National Cancer Institute US
• University of Rochester US
• Okayama University JP
• Wake Forest University US
• Medical University of Graz AT
• Samsung Medical Center KR
• Instituto de Investigación Biomédica de Salamanca ES
• Centro de Investigación del Cáncer ES
• Ludwig-Maximilians-Universität München DE
• Karolinska Institutet SE
• Universidad Autónoma de Madrid ES
• Peter MacCallum Cancer Centre AU
• University of Bologna IT
• IRCCS Ospedale San Raffaele IT
• Northwestern University US
• Cancer Research UK GB
• Universidad de Salamanca ES
• European Institute of Oncology IT
• Ente Ospedaliero Cantonale CH
• Nagoya University Hospital JP
• Dana-Farber Cancer Institute US
• University of Basel CH
• Universitat de Barcelona ES
• Cornell University US
• Memorial Sloan Kettering Cancer Center US
• Clinica Universidad de Navarra ES
• Mayo Clinic in Arizona US
• Sungkyunkwan University KR
• WinnMed US
• Center for Cancer Research US
• University of Tübingen DE
• Università della Svizzera italiana CH
• Institut Necker Enfants Malades FR
• Mayo Clinic US
• Hôpital Saint-Louis FR
• University Hospital Münster DE
• Consorci Institut D'Investigacions Biomediques August Pi I Sunyer ES
• Instituto Nacional de Enfermedades Neoplásicas PE
• City Of Hope National Medical Center US
• Mayo Clinic in Florida US
• Aarhus University Hospital DK
• Navarre Institute of Health Research ES
• The Royal Melbourne Hospital AU
• NHS Greater Glasgow and Clyde GB
• National Health Service GB
• Institute of Oncology Research CH
• Hôpitaux Universitaires Henri-Mondor FR
• University of Nebraska Medical Center US
• National Institutes of Health US
• Cleveland Clinic US
• University of Southampton GB
• National Institute of Allergy and Infectious Diseases US
• Southampton General Hospital GB
• Délégation Paris 7 FR
• National University of San Marcos PE
• University of Chicago US
• University of Pittsburgh US
• Inserm FR
• Universitair Ziekenhuis Leuven BE
• Stanford University US
• Paris-Est Sup FR
• Vita-Salute San Raffaele University IT
• Stanford Blood Center US
• University of Perugia IT
• BC Cancer Agency CA
• Queen Mary University of London GB
• Centro de Investigación Biomédica en Red de Cáncer ES
• Hôpital Necker-Enfants Malades FR
• Université Paris-Est Créteil FR
• Washington University in St. Louis US
• University of Lausanne CH
• Academia Nacional de Medicina AR

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