Abstract
The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. NF-kappaB has long been considered the "holy grail" as a target for new anti-inflammatory drugs; however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease. In this article, we discuss the role of NF-kappaB in inflammation in light of these recent studies.
Keywords
Proinflammatory cytokineInflammationBiologyNF-κBChemokineSignal transductionNFKB1Cell biologyImmunologyHoly GrailTranscription factorGeneGenetics
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Publication Info
- Year
- 2009
- Type
- review
- Volume
- 1
- Issue
- 6
- Pages
- a001651-a001651
- Citations
- 4580
- Access
- Closed
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Cite This
Toby Lawrence
(2009).
The Nuclear Factor NF- B Pathway in Inflammation.
Cold Spring Harbor Perspectives in Biology
, 1
(6)
, a001651-a001651.
https://doi.org/10.1101/cshperspect.a001651
Identifiers
- DOI
- 10.1101/cshperspect.a001651