The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers

Keywords

GTPaseOncologyInternal medicineMedicineSmall GTPaseBiologyCancer researchSignal transductionCell biology

Affiliated Institutions

Related Publications

Nitric Oxide Controls Src Kinase Activity through a Sulfhydryl Group Modification-mediated Tyr-527-independent and Tyr-416-linked Mechanism

Anwarul Azim Akhand , Mei‐yi Pu , Masashi Kato +5 more

c-Src kinase was activated when either murine NIH3T3 fibroblast cells or immunoprecipitated c-Src proteins were treated with nitric oxide generator, S-nitroso-N-acetyl penicilla...

1999 Journal of Biological Chemistry 165 citations

c-Src Is Required for Oxidative Stress-mediated Activation of Big Mitogen-activated Protein Kinase 1 (BMK1)

Jun‐ichi Abe , Masafumi Takahashi , Mari Ishida +2 more

Big mitogen-activated kinase 1 (BMK1) or extracellular signal-regulated kinase-5 (ERK5) has recently been identified as a new member of the mitogen-activated protein kinase fami...

1997 Journal of Biological Chemistry 272 citations

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

Massimo Sargiacomo , Marius Sudol , Zhenyong Tang +1 more

GPI-linked protein molecules become Triton-insoluble during polarized sorting to the apical cell surface of epithelial cells. These insoluble complexes, enriched in cholesterol,...

1993 The Journal of Cell Biology 956 citations

Fyn and JAK2 Mediate Ras Activation by Reactive Oxygen Species

Jun‐ichi Abe , Bradford C. Berk

Reactive oxygen species (ROS) activate Ras and the extracellular signal-regulated kinase (ERK) cascade. Because JAK2 is a critical mediator for Ras/Raf/ERK activation by several...

1999 Journal of Biological Chemistry 206 citations

Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome

Richard W. Tothill , Anna V. Tinker , Joshy George +15 more

Abstract Purpose: The study aim to identify novel molecular subtypes of ovarian cancer by gene expression profiling with linkage to clinical and pathologic features. Experimenta...

2008 Clinical Cancer Research 1472 citations

Publication Info

Year: 2004
Type: article
Volume: 10
Issue: 11
Pages: 1251-1256
Citations: 510
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

510

OpenAlex

Cite This

APA Style

                            
                                
                                    Kwai Wa Cheng, 
                                
                                    John Lahad, 
                                
                                    Wen-Lin Kuo
                                
                                et al.
                            
                            (2004). 
                            The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. 
                            Nature Medicine
                            , 10
                            (11)
                            , 1251-1256.
                            https://doi.org/10.1038/nm1125
                        

Identifiers

DOI: 10.1038/nm1125