The RESID Database of Protein Modifications as a resource and annotation tool

Abstract

Abstract The RESID Database of Protein Modifications is a comprehensive collection of annotations and structures for protein modifications and cross‐links including pre‐, co‐, and post‐translational modifications. The database provides: systematic and alternate names, atomic formulas and masses, enzymatic activities that generate the modifications, keywords, literature citations, Gene Ontology (GO) cross‐references, protein sequence database feature table annotations, structure diagrams, and molecular models. This database is freely accessible on the Internet through resources provided by the European Bioinformatics Institute (http://www.ebi.ac.uk/RESID), and by the National Cancer Institute – Frederick Advanced Biomedical Computing Center (http://www.ncifcrf.gov/RESID). Each RESID Database entry presents a chemically unique modification and shows how that modification is currently annotated in the protein sequence databases, Swiss‐Prot and the Protein Information Resource (PIR). The RESID Database provides a table of corresponding equivalent feature annotations that is used in the UniProt project, an international effort to combine the resources of the Swiss‐Prot, TrEMBL and PIR. As an annotation tool, the RESID Database is used in standardizing and enhancing modification descriptions in the feature tables of Swiss‐Prot entries. As an Internet resource, the RESID Database assists researchers in high‐throughput proteomics to search monoisotopic masses and mass differences and identify known and predicted protein modifications.

Keywords

Affiliated Institutions

• European Bioinformatics Institute GB

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