Abstract

SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases. Recent developments of the database include format and content enhancements, cross-references to additional databases, new documentation files and improvements to TrEMBL, a computer-annotated supplement to SWISS-PROT. TrEMBL consists of entries in SWISS-PROT-like format derived from the translation of all coding sequences (CDSs) in the EMBL Nucleotide Sequence Database, except the CDSs already included in SWISS-PROT. We also describe the Human Proteomics Initiative (HPI), a major project to annotate all known human sequences according to the quality standards of SWISS-PROT. SWISS-PROT is available at: http://www.expasy.ch/sprot/ and http://www.ebi.ac.uk/swissprot/

Keywords

UniProtSequence databaseAnnotationBiologyProtein sequencingDocumentationDatabaseProteomicsComputational biologyBioinformaticsInformation retrievalPeptide sequenceComputer scienceGeneticsProgramming language

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Related Publications

The Universal Protein Resource (UniProt)

Amos Bairoch

The Universal Protein Resource (UniProt) provides the scientific community with a single, centralized, authoritative resource for protein sequences and functional information. F...

2004 Nucleic Acids Research 3760 citations

Publication Info

Year
2000
Type
article
Volume
28
Issue
1
Pages
45-48
Citations
3110
Access
Closed

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Amos Bairoch, Rolf Apweiler (2000). The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Research , 28 (1) , 45-48. https://doi.org/10.1093/nar/28.1.45

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DOI
10.1093/nar/28.1.45