Abstract
For decades, research into cancer biology focused on the involvement of protein-coding genes. Only recently was it discovered that an entire class of molecules, termed non-coding RNA (ncRNA), plays key regulatory roles in shaping cellular activity. An explosion of studies into ncRNA biology has since shown that they represent a diverse and prevalent group of RNAs, including both oncogenic molecules and those that work in a tumor suppressive manner. As a result, hundreds of cancer-focused clinical trials involving ncRNAs as novel biomarkers or therapies have begun and these are likely just the beginning.
Keywords
BiologyComputational biologyCoding (social sciences)Long non-coding RNAMolecular oncologyGeneticsRNACancerGeneCarcinogenesis
MeSH Terms
BiomarkersTumorClinical Trials as TopicHumansMedical OncologyNeoplasmsOncogenesRNAUntranslated
Affiliated Institutions
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Publication Info
- Year
- 2019
- Type
- review
- Volume
- 179
- Issue
- 5
- Pages
- 1033-1055
- Citations
- 1612
- Access
- Closed
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Cite This
Frank J. Slack,
Arul M. Chinnaiyan
(2019).
The Role of Non-coding RNAs in Oncology.
Cell
, 179
(5)
, 1033-1055.
https://doi.org/10.1016/j.cell.2019.10.017
Identifiers
- DOI
- 10.1016/j.cell.2019.10.017
- PMID
- 31730848
- PMCID
- PMC7347159