Transcriptional Regulatory Networks in Saccharomyces cerevisiae

Abstract

We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators.

Keywords

Saccharomyces cerevisiaeEukaryoteGene regulatory networkComputational biologyGeneTranscriptional regulationBiologyRegulatorRegulation of gene expressionGeneticsGenomeYeastGene expression

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Publication Info

Year: 2002
Type: article
Volume: 298
Issue: 5594
Pages: 799-804
Citations: 2972
Access: Closed

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APA Style

                            
                                
                                    Tong Ihn Lee, 
                                
                                    Nicola J. Rinaldi, 
                                
                                    François Robert
                                
                                et al.
                            
                            (2002). 
                            Transcriptional Regulatory Networks in <i>Saccharomyces cerevisiae</i>. 
                            Science
                            , 298
                            (5594)
                            , 799-804.
                            https://doi.org/10.1126/science.1075090
                        

Identifiers

DOI: 10.1126/science.1075090