Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer

Abstract

In this trial involving patients with HER2-low metastatic breast cancer, trastuzumab deruxtecan resulted in significantly longer progression-free and overall survival than the physician's choice of chemotherapy. (Funded by Daiichi Sankyo and AstraZeneca; DESTINY-Breast04 ClinicalTrials.gov number, NCT03734029.).

Keywords

Affiliated Institutions

• Vall d'Hebron Institute of Oncology
• Université Paris Cité FR
• University of Ulsan KR
• Yonsei University Health System KR
• Institut Jules Bordet BE
• Tokai University JP
• National Hospital Organization Kyushu Cancer Center JP
• First Hospital of Jilin University CN
• The University of Texas MD Anderson Cancer Center US
• Jilin University CN
• National University College PR
• Université de Montpellier FR
• Institut Català d'Oncologia ES
• Samsung Medical Center KR
• Ludwig-Maximilians-Universität München DE
• Peking Union Medical College Hospital CN
• University Health System US
• Kanagawa Prefectural Hospital Organization JP
• Hospital Clínic de Barcelona ES
• Daiichi Sankyo (United States) US
• Institut Curie FR
• Sun Yat-sen Memorial Hospital CN
• Showa University Hospital JP
• Universitat de Barcelona ES
• Memorial Sloan Kettering Cancer Center US
• Seoul National University Hospital KR
• National Cancer Center KR
• Asan Medical Center KR
• Institut de Recherche en Cancérologie de Montpellier FR
• UCSF Helen Diller Family Comprehensive Cancer Center US
• Edinburgh Cancer Research GB
• Breast Cancer Research Foundation US
• Rabin Medical Center IL
• Alexandra Hospital GR
• West China Hospital of Sichuan University CN
• Kanagawa Cancer Center
• Sun Yat-sen University CN
• Kyungpook National University Hospital KR
• Duran i Reynals Hospital ES
• New Generation University College ET
• Cleveland Clinic US
• Tel Aviv University IL
• Inserm FR
• Hebron University PS
• Queen Mary University of London GB
• Target (United States) US
• Ulsan College KR
• Zhejiang Cancer Hospital CN
• University of California, San Francisco US
• Chinese Academy of Medical Sciences & Peking Union Medical College CN
• Liaoning Cancer Hospital & Institute CN
• Sichuan University CN

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