Abstract

SOLID tumors are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.1 , 2 In tumors of epithelialcell origin — carcinomas — a basement membrane is often interposed between the tumor cells and the stroma, but in other types of tumors, malignant cells directly abut on or intermingle with stromal elements.1 , 3 An appreciation of tumor stroma is essential to an understanding of the biology of tumor growth; all solid tumors, regardless of their site of origin, require stroma if they are to grow beyond a minimal size of . . .

Keywords

StromaStromal cellPathologyTumor cellsBasement membraneMedicineCancer researchBiologyImmunohistochemistry

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Publication Info

Year
1986
Type
review
Volume
315
Issue
26
Pages
1650-1659
Citations
4284
Access
Closed

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Jeffrey S. Flier, Lisa H. Underhill, Harold F. Dvorak (1986). Tumors: Wounds That Do Not Heal. New England Journal of Medicine , 315 (26) , 1650-1659. https://doi.org/10.1056/nejm198612253152606

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DOI
10.1056/nejm198612253152606