Up-regulation of beta-actin, cyclophilin and GAPDH in N1S1 rat hepatoma.

Tung‐Yao Chang; Chi‐Chang Juan; Pen-Hui Yin; C W; Huey‐Jen Tsay

doi:10.3892/or.5.2.469

Abstract

Beta-actin, cyclophilin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are all constantly expressed proteins that regulate cellular structures and endogenous cytoarchitectural functions. In this study, we used an in vivo N1S1 rat hepatoma model to examine changes in the expression levels of these housekeeping genes in normal and tumor liver samples. The beta-actin, cyclophilin and GAPDH genes were all up-regulated in tumor groups as compared to the controls. Our results suggest that up-regulation of beta-actin, cyclophilin and GAPDH genes may be essential for oncogenesis in hepatoma.

Keywords

Glyceraldehyde 3-phosphate dehydrogenaseCyclophilin ABiologyCyclophilinHousekeeping geneActinCarcinogenesisCell biologyGeneOncogeneMolecular biologyCell cycleGene expressionBiochemistry

Affiliated Institutions

Taipei Veterans General Hospital TW

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Publication Info

Year: 1998
Type: article
Volume: 5
Issue: 2
Pages: 469-71
Citations: 72
Access: Closed

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APA Style

                            
                                
                                    Tung‐Yao Chang, 
                                
                                    Chi‐Chang Juan, 
                                
                                    Pen-Hui Yin
                                
                                et al.
                            
                            (1998). 
                            Up-regulation of beta-actin, cyclophilin and GAPDH in N1S1 rat hepatoma.. 
                            Oncology Reports
                            , 5
                            (2)
                            , 469-71.
                            https://doi.org/10.3892/or.5.2.469
                        

Identifiers

DOI: 10.3892/or.5.2.469