Viral and host factors related to the clinical outcome of COVID-19

Xiaonan Zhang; Yun Tan; Yun Ling; Gang Lü; Feng Liu; Zhigang Yi; Xiaofang Jia; Min Wu; Bisheng Shi; Shuibao Xu; Jun Chen; Wei Wang; Bing Chen; Lu Jiang; Shuting Yu; Jing Lu; Jinzeng Wang; Mingzhu Xu; Zhenghong Yuan; Qin Zhang; Xinxin Zhang; Guoping Zhao; Shengyue Wang; Sai‐Juan Chen; Hongzhou Lu

doi:10.1038/s41586-020-2355-0

Keywords

LymphocytopeniaCytokine stormOutbreakCoronavirusDiseasePandemicImmunologyMedicineEpidemiologyBiologyVirologyCoronavirus disease 2019 (COVID-19)Internal medicineLymphocyteInfectious disease (medical specialty)

Affiliated Institutions

Related Publications

SARS-CoV-2: a storm is raging

Savannah F. Pedersen , Ya‐Chi Ho

The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this is...

2020 Journal of Clinical Investigation 1206 citations

Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study

Li Tan , Qi Wang , Duanyang Zhang +5 more

Background: Coronavirus disease-2019 (COVID-19) is a rapidly escalating epidemic caused by SARS-CoV-2. Identification of a simple and effective indicator to assess disease sever...

2020 Signal Transduction and Targeted Therapy 1583 citations

COVID-19: immunopathology and its implications for therapy

Xuetao Cao

Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; h...

2020 Nature reviews. Immunology 1680 citations

The cytokine storm and COVID‐19

Biying Hu , Shaoying Huang , Lianghong Yin

Abstract Coronavirus disease 2019 (COVID‐19), which began in Wuhan, China, in December 2019, has caused a large global pandemic and poses a serious threat to public health. More...

2020 Journal of Medical Virology 1624 citations

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

Yixuan J. Hou , Kenichi Okuda , Caitlin E. Edwards +40 more

The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease 2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a ...

2020 Cell 1608 citations

Publication Info

Year: 2020
Type: article
Volume: 583
Issue: 7816
Pages: 437-440
Citations: 981
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Viral and host factors related to the clinical outcome of COVID-19

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

981

OpenAlex

Cite This

APA Style

                            
                                
                                    Xiaonan Zhang, 
                                
                                    Yun Tan, 
                                
                                    Yun Ling
                                
                                et al.
                            
                            (2020). 
                            Viral and host factors related to the clinical outcome of COVID-19. 
                            Nature
                            , 583
                            (7816)
                            , 437-440.
                            https://doi.org/10.1038/s41586-020-2355-0
                        

Identifiers

DOI: 10.1038/s41586-020-2355-0