Wild-type p53 activates transcription in vitro

George E. Farmer; Jill Bargonetti; Hua Zhu; Paula N. Friedman; Ron Prywes; Carol Prives

doi:10.1038/358083a0

Keywords

Transcription (linguistics)MutantWild typeTranscription factorMolecular biologyBiologyCell biologyIn vitroGeneral transcription factorResponse elementGenePromoterGene expressionGenetics

Affiliated Institutions

Columbia University US

Related Publications

Repression of the basal c-fos promoter by wild-type p53

Nikolai Kley , Richard Y. Chung , Sandra Fay +2 more

Mutations in the p53 gene are the most common genetic alterations observed in many inherited and sporadic forms of human cancer. Recent studies indicate that wild-type p53 may b...

1992 Nucleic Acids Research 90 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

Scott E. Kern , Jennifer A. Pietenpol , Sam Thiagalingam +3 more

Mutant forms of the gene encoding the tumor suppressor p53 are found in numerous human malignancies, but the physiologic function of p53 and the effects of mutations on this fun...

1992 Science 343 citations

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

Philip Friedlander , Ygal Haupt , Carol Prives +1 more

Human wild-type (wt) p53 can induce apoptosis in transiently transfected H1299 cells maintained at 37 degrees C, whereas tumor-derived mutant forms of p53 (with the mutation Ala...

1996 Molecular and Cellular Biology 278 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

Ygal Haupt , Sheldon Rowan , Eitan Shaulian +2 more

The p53 tumor suppressor protein is a transcriptional activator, which can mediate apoptotic cell death in a variety of cell types. To determine whether sequence-specific trans-...

1995 Genes & Development 544 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

Stanley Fields , Sung Key Jang

The p53 gene is frequently mutated in a wide variety of human cancers. However, the role of the wild-type p53 gene in growth control is not known. Hybrid proteins that contain t...

1990 Science 812 citations

Publication Info

Year: 1992
Type: article
Volume: 358
Issue: 6381
Pages: 83-86
Citations: 591
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Wild-type p53 activates transcription in vitro

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

591

OpenAlex

Cite This

APA Style

                            
                                
                                    George E. Farmer, 
                                
                                    Jill Bargonetti, 
                                
                                    Hua Zhu
                                
                                et al.
                            
                            (1992). 
                            Wild-type p53 activates transcription in vitro. 
                            Nature
                            , 358
                            (6381)
                            , 83-86.
                            https://doi.org/10.1038/358083a0
                        

Identifiers

DOI: 10.1038/358083a0