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Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
Chromosomal Mapping The conformation of the genome in the nucleus and contacts between both proximal and distal loci influence gene expression. In order to map genomic contacts,...
RNA-Guided Human Genome Engineering via Cas9
Genome Editing Clustered regularly interspaced short palindromic repeats (CRISPR) function as part of an adaptive immune system in a range of prokaryotes: Invading phage and pla...
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
This study showed that mismatch-repair status predicted clinical benefit of immune checkpoint blockade with pembrolizumab. (Funded by Johns Hopkins University and others; Clinic...
Solar Water Splitting Cells
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.Solar Water Splitting CellsMichael G. Walter, Emily L. Warren, J...
Statistical-Mechanical Theory of Irreversible Processes. I. General Theory and Simple Applications to Magnetic and Conduction Problems
A general type of fluctuation-dissipation theorem is discussed to show that the physical quantities such as complex susceptibility of magnetic or electric polarization and compl...
Enzymatic Determination of Total Serum Cholesterol
Abstract An enzymatic method is described for determination of total serum cholesterol by use of a single aqueous reagent. The method requires no prior treatment of sample and t...
Emerging Photoluminescence in Monolayer MoS<sub>2</sub>
Novel physical phenomena can emerge in low-dimensional nanomaterials. Bulk MoS(2), a prototypical metal dichalcogenide, is an indirect bandgap semiconductor with negligible phot...
Science in action : how to follow scientists and engineers through society
Acknowledgements Introduction Opening Pandora's Black Box PART I FROM WEARER TO STRONGER RHETORIC Chapter I Literature Part A: Controversies Part B: When controversies flare up ...
The Fluid Mosaic Model of the Structure of Cell Membranes
A fluid mosaic model is presented for the gross organization and structure of the proteins and lipids of biological membranes. The model is consistent with the restrictions impo...