Diagnosis of Alzheimer's Disease
Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. To address the problems involved in diagnosing AD in its ear...
Publications
Explore 316 academic publications
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316 publications
Cross-Validatory Estimation of the Number of Components in Factor and Principal Components Models
By means of factor analysis (FA) or principal components analysis (PCA) a matrix Y with the elements y ik is approximated by the model Here the parameters α, β and θ express the...
A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma
Abstract The recognition of several new types of non-Hodgkin's lymphoma (NHL) in recent years has led to proposals for changing lymphoma classifications, including a new proposa...
Structural Equation Modeling and Natural Systems
This book, first published in 2006, presents an introduction to the methodology of structural equation modeling, illustrates its use, and goes on to argue that it has revolution...
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse, which is associated with clonal evolution at the cytogenetic level. To determine the...
European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
Abstract Advances in chronic myeloid leukemia treatment, particularly regarding tyrosine kinase inhibitors, mandate regular updating of concepts and management. A European Leuke...
Spontaneous Symmetry Breakdown without Massless Bosons
We examine a simple relativistic theory of two scalar fields, first discussed by Goldstone, in which as a result of spontaneous breakdown of $U(1)$ symmetry one of the scalar bo...
Cancer Disparities by Race/Ethnicity and Socioeconomic Status
This article highlights disparities in cancer incidence, mortality, and survival in relation to race/ethnicity, and census data on poverty in the county or census tract of resid...
Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies
Abstract Too many reports of associations between genetic variants and common cancer sites and other complex diseases are false positives. A major reason for this unfortunate si...
Problems of Spectrum and Bias in Evaluating the Efficacy of Diagnostic Tests
To determine why many diagnostic tests have proved to be valueless after optimistic introduction into medical practice, we reviewed a series of investigations and identified two...
Supplementary motor area and other cortical areas in organization of voluntary movements in man
1. Previous studies in man have revealed a coupling between the regional cerebral blood flow (rCBF) and the regional cerebral metabolic rate for oxygen. In normal man, increases...
Explaining the Limited Effectiveness of Legalistic “Remedies” for Trust/Distrust
Organizations frequently adopt formal rules, contracts, or other legalistic mechanisms when interpersonal trust is lacking. But recent research has shown such legalistic “remedi...