Modified RECIST (mRECIST) Assessment for Hepatocellular Carcinoma
The endpoint in cancer research is overall survival. Nonetheless, other potential surrogate endpoints, such as response rate and time to progression, are currently used. Measure...
Publications
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1,434 publications
In Situ Formation of an Oxygen-Evolving Catalyst in Neutral Water Containing Phosphate and Co <sup>2+</sup>
The utilization of solar energy on a large scale requires its storage. In natural photosynthesis, energy from sunlight is used to rearrange the bonds of water to oxygen and hydr...
Cancer Statistics, 2004
Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on...
Haplotype-based variant detection from short-read sequencing
The direct detection of haplotypes from short-read DNA sequencing data requires changes to existing small-variant detection methods. Here, we develop a Bayesian statistical fram...
Extraterrestrial Cause for the Cretaceous-Tertiary Extinction
Platinum metals are depleted in the earth's crust relative to their cosmic abundance; concentrations of these elements in deep-sea sediments may thus indicate influxes of extrat...
The earth is round (p < .05).
After 4 decades of severe criticism, the ritual of null hypothesis significance testing (mechanical dichotomous decisions around a sacred .05 criterion) still persists. This art...
Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group
Purpose Patients with advanced pancreatic cancer have a poor prognosis and there have been no improvements in survival since the introduction of gemcitabine in 1996. Pancreatic ...
Transtheoretical therapy: Toward a more integrative model of change.
Transtheoretical therapy is presented as one alternative within the Zeitgeist seeking a synthesis for the increasing proliferation of therapeutic systems. From a comparative ana...
The Pfam protein families database
Pfam is a widely used database of protein families, currently containing more than 13 000 manually curated protein families as of release 26.0. Pfam is available via servers in ...
Microbial diversity in the deep sea and the underexplored “rare biosphere”
The evolution of marine microbes over billions of years predicts that the composition of microbial communities should be much greater than the published estimates of a few thous...
ERA5-Land: a state-of-the-art global reanalysis dataset for land applications
Abstract. Framed within the Copernicus Climate Change Service (C3S) of the European Commission, the European Centre for Medium-Range Weather Forecasts (ECMWF) is producing an en...
Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
We found that autosomal dominant Alzheimer's disease was associated with a series of pathophysiological changes over decades in CSF biochemical markers of Alzheimer's disease, b...